Wednesday, January 21, 2015

In memory of Hannah Warren (2010 – 2013)

Hannah Genevieve Warren was born on August 22, 2010 at Dongguk University Ilsan Hospital in Goyang-si, Gyeonggi Province (where her parents lived). When she was born she was blue. Doctors spent about five minutes resuscitating her. Hannah developed a bronchoesophageal fistula which enabled doctors to revive her after birth. Doctors inserted a tube through her esophagus and into her lungs and discovered she did not have a trachea. She was transferred to Seoul National Hospital. Hannah's esophagus often secretes mucous and the secretions sometimes flow towards her lungs, so her tube has to be suctioned every fifteen minutes, which is why she never left the hospital. Hannah often drains her own saliva onto the tube and into her lungs, basically drowning in her own saliva, and if the saliva wasn't suctioned, she would die. Hannah contracted pneumonia numerous times and was pulled out of many life threatening situations.

Dr. Mark Holterman (Children's Hospital of Illinois) first met Hannah on a business trip. He by chance went back to Seoul a 5 months later for a stem cell conference and met Hannah again. The second time he met the family in tears and they told him "we don't know what to do, our daughter is a prisoner in the hospital" and asked him to contact Dr. Paolo Macchiarini, which he promised to do when he gets back to Illinois. Dr. Macchiarini responded the very next day volunteering to help. Dr. Holterman arranged to have the surgery in Children's Hospital of Illinois. In early March 2013 they visited Seoul to do some final testing and found that Hannah had issues with her esophagus and four major arteries, which would further complicate the surgery, but they determined the transplant could proceed. They took stem cells from Hannah's hip bone. Hannah had her surgery on April 9th, not only receiving a new trachea, but an operation on her esophagus as well, and then was breathing through a tracheostomy tube. Hannah is being cared for by a team including pulmonologists, hematologists, intensivist, nurses, respiratory therapists, physical, occupational and speech therapists, and supportive services. On April 16 she was breathing on her own. On June 11, Hannah had  a second operation for a leak in her esophagus, and died on Saturday, July 6, 2013 of lung complications. Her native tissue was too fragile for the operation to work. "The trachea was never a problem," Dr. Macchiarini said. "It was her native tissue that was very fragile."
Hannah at Seoul National University Hospital – https://www.youtube.com/watch?v=qVXsRMRmsO4
Hannah getting presents from her older sister Dana – https://www.youtube.com/watch?v=u7JwPXAIry4
Mark Holterman contacts Paolo Macchiarini –  https://www.youtube.com/watch?v=cOMt8ZyrB4Y
Paolo arrives at Seoul National University Hospital –  https://www.youtube.com/watch?v=NP_5WT5sX9Q
Paolo Macchiarini meets Mark Holterman –  https://www.youtube.com/watch?v=gboqPE9Q9IY
Paolo talks to Hannah (skip to 2:35 to see Paolo talking to Hannah) –  https://www.youtube.com/watch?v=lR6PwKNW11w
Paolo and Mark Holterman consulting the parents about the surgery –  https://www.youtube.com/watch?v=1MuCvfrKrSI
Hannah Warren windpipe transplant bioreactor preparation –  https://www.youtube.com/watch?v=vmUFpFcRkXQ
Hannah arriving at Children's Hospital of Illinois –  https://www.youtube.com/watch?v=jw0L_n4zD1c
Hannah meeting her Canadian grandparents –  https://www.youtube.com/watch?v=xl5j9kPovas
Hannah's surgery (warning graphic) –  https://www.youtube.com/watch?v=wNwYfYg2YEY
Hannah finishing operation –  https://www.youtube.com/watch?v=MG-MOednU2w
2013 Children's Hospital of Illinois Telethon Miracle Child- Hannah Warren –  https://www.youtube.com/watch?v=ycSHk26LsuA
Child gets trachea made from own stem cells –  https://www.youtube.com/watch?v=bjPHI1sCZ4E
Girl, 2, makes medical history with stem cell surgery –  https://www.youtube.com/watch?v=S__CJvaF9JE
Girl has first ever stem cell trachea transplant –  https://www.youtube.com/watch?v=2Ts1P8bOe7M
Tributes to Hannah –  https://www.youtube.com/watch?v=sGODmn3jLxw
When will Hannah Receive Her New Trachea? When will Hannah Receive Her New Trachea?
Young Girl Receives Lifesaving Windpipe Transplant Made From Her Stem Cells –  http://healthland.time.com/2013/04/30/young-girl-undergoes-successful-windpipe-transplant-from-her-stem-cells/
Hannah Warren, first child to receive windpipe made from stem cells, dies –  http://natmonitor.com/2013/07/10/hannah-warren-first-child-to-receive-windpipe-made-from-stem-cells-dies/
Raising glasses to help baby Hannah –  http://www.koreaherald.com/view.php?ud=20110817000789
Little Hannah Warren waiting on groundbreaking windpipe transplant surgery –http://www.koreaherald.com/view.php?ud=20110629000804&mod=skb
Stem cell windpipe gives Korean toddler new life –  http://www.koreaherald.com/view.php?ud=20130501000575&mod=skb
Girl given stem cell windpipe dies –  http://www.koreaherald.com/view.php?ud=20130708000906&mod=skb
Help Hannah Breathe (fundraiser for surgery) –  https://www.giveforward.com/fundraiser/qbr/helphannahbreathe
Hannah’s Story Children’s hospital of Illinois –  http://www.childrenshospitalofillinois.org/trachea-surgery/
Trachea Transplant at Children's Hospital of Illinois Gives Korean Toddler New Windpipe –  http://www.childrenshospitalofillinois.org/trachea-surgery/press.html
Two-Year Old Girl Receives Man-made Trachea Implant in First-of-its-Kind Surgery –  http://www.childrenshospitalofillinois.org/trachea-surgery/pdfs/BioSpherix-Release.pdf
Young Girl Given Bioengineered Windpipe Dies –  http://www.nytimes.com/2013/07/08/science/young-girl-given-bioengineered-windpipe-dies.html

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